Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane
نویسندگان
چکیده
Myoglobin (Mb) interaction with the outer mitochondrial membrane (OMM) promotes oxygen (O2) release. However, comprehensive molecular details on specific contact regions of OMM oxygenated (oxy-) and deoxygenated (deoxy-)Mb are missing. We used dynamics (MD) simulations to explore oxy- deoxy-Mb lipids in two lipid compositions: (a) a typical whole average, (b) specifically cardiolipin-enriched cristae region (contact site). Unrestrained relaxations showed that both established more stable contacts site, then those average OMM. steered detachment simulations, clung tightly OMM, oxy-Mb strongly preferred sites The MD simulation analysis further indicated non-specific binding, mediated by local electrostatic interactions, existed between charged or polar groups Mb membrane, for interaction. To best our knowledge, this is first computational study providing direct Mb–mitochondria assisted distinguishing localization Our findings support existing experimental evidence Mb–mitochondrial association shed insights Mb-mediated O2 transport cellular bioenergetics.
منابع مشابه
A COMPARATIW STUDY ON THE BINDING OF HEXOKINASE TO THE OUTER MITOCHONDRIAL MEMBRANE AND A HYDROPHOBIC MATRIX
متن کامل
a comparatiw study on the binding of hexokinase to the outer mitochondrial membrane and a hydrophobic matrix
0
متن کاملthe analysis of the role of the speech acts theory in translating and dubbing hollywood films
از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
15 صفحه اولthe differential effects of debate and media analysis as relate to enhancing efl learners critical thinking ability and writing performances
critical thinking ability has an important role in education. accordingly, scholars around the world are searching for new ways for teaching and improving students critical thinking ability. in line with the studies in efl contexts supporting the positive relationship between critical thinking and writing performances, this study investigated the differential effects of halverson’s critical thi...
15 صفحه اولconsequence analysis of the leakage, ignition and explosion during high pressure sour gas injection process to the oil reservoir
there is no doubt that human being needs to become integrated with industry and industry needs to be progressed, daily. on the other hand, serious events in industrial units specially in oil industries has been shown that such damages and events are industry related ones. the consequence of such events and damages which resulted in chemical and poisoned explosions and loss of life and property ...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomolecules
سال: 2023
ISSN: ['2218-273X']
DOI: https://doi.org/10.3390/biom13071138